THE EFFECT OF DIETARY CAYENNE PEPPER SUPPLEMENTATION ON THE METABOLIC DYSREGULATION OF RATS IN VIVO Running Head: Effects of cayenne pepper on metabolic dysregulation
نویسنده
چکیده
Background: Metabolic dysregulation is a hallmark of diseases such as Type 2 diabetes, Cancer, and Cardiovascular disease (1). Purpose: In this study, we assessed whether dietary capsaicin in the form of cayenne pepper improves the risk factors of metabolic dysregulation in atherogenic diet-fed rats with inflammation. Procedure: Forty rats were divided into four groups with 50% consuming a control atherogenic diet, and the other 50% consuming a cayenne pepper (2.9%;0.015% capsaicin) atherogenic rat diet for 4 weeks. One group from each diet type were administered an inflammation inducing agent (DSS) after the four week process. All four groups were then tested for inflammatory markers (Creactive Protein), lipid profile, glucose tolerance, serum albumin, epididymal fat and various organ weights. Results: Treatment effect caused significance in food (p=0.004) and water (p=0.016) intake during DSS. Diet effect accounted for significance of final body weight (p=0.045), final weight gain (p=0.022), epididymal fat measurement (p=0.037), triglycerides (p=0.031), total cholesterol (p=0.038), high-density lipoprotein (p=0.045), low-density lipoprotein (p=0.031), and C-reactive protein (p=0.043). No significance found (p<0.05) in initial body weight, food or water intake before or after DSS treatment, liver, spleen, or kidney weight, albumin, or glucose. Conclusion: Cayenne pepper reduces the risk factors of metabolic dysregulation by favorable changes of body weight gain, body fat, lipid profile and inflammation.
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تاریخ انتشار 2013